Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
According to Feng Zhenglin, head of the Civil Aviation Administration of China, weather accounted for 56.8% of flight delays in 2016, up from 29.5% the previous year.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
over $50,000 category, pickups and SUVs distributed through non-premium dealers outsell German luxury brands.
Continued experimentation with wearables is important, but the near-term requires a conversation “about whether current wearables, driven by a combination of organic efforts and corporate tech efforts, are really adhering to customer needs and wants or if companies need to explore a different set of partnerships to push wearables beyond early adopters and into the mainstream,” Gilbert says.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
John Hummel, chief investment officer for AIS Group, a fund manager with $400 million under management, said all the new sources of global oil are expensive to extract, and he sees U.S. shale output falling by 2015.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
‘Veep’ “House of Cards,” the Netflix phenomenon, showed its weaknesses this year, but HBO’s “Veep,” the other most cynical show about Washington, got stronger in its third season. The scene in a restroom in which Selina (Julia Louis-Dreyfus) and her assistant, Gary (Tony Hale) discover that she is going to become president and dissolve into uncontrollable laughter was one of the great comic moments of 2014.
Diagnostic technologies for COVID-19: a review
《她》(Her)，由斯派克?琼斯(Spike Jonze)担任编剧兼导演，将浪漫带入了虚拟世界，影片的主人公展开了一场有些疯狂的真正激情之旅。华金?菲尼克斯(Joaquin Phoenix)扮演的男主角是个令人心酸的孤独小伙子，他爱上了自己智能手机的新操作系统。影片的基本构想有些脆弱，但故事非常华丽地展开，霍伊特?范?霍特玛(Hoyte Van Hoytema)的摄影也很精妙，完美地烘托了菲尼克斯、艾米?亚当斯(Amy Adams)和斯嘉丽?约翰逊(Scarlett Johansson)的表演。斯嘉丽?约翰逊在片中扮演的是智能手机操作系统的声音和灵魂。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
In the meantime, the sheer total of bitcoin-related startups that launched in 2014 demonstrates bitcoin’s momentum. There is no definitive listing of every single bitcoin startup, but 2014 almost certainly saw the launch of more of them than in any year prior. Data that AngelList sent to Fortune confirms that. In 2011, five bitcoin startups listed themselves on AngelList. In 2012 that number grew to 13. In 2013 it jumped to 193, and last year it exploded to 566. (But not all startups register on AngelList immediately, if at all.) In addition, on January 8 the total number of daily bitcoin transactions hit an all-time high, as Barry Silbert eagerly tweeted.
But that recovery has also seen the size of bonuses drop: last year the average payout was Rmb12,821 ($1,861), about Rmb2,000 more than in 2015 but still roughly Rmb800 below the 2014 average. More than a quarter of those surveyed who saw their bonus shrink last year blamed the decrease on poor company performance.
Global smartphone shipments reached 1.47 billion units in 2016, up by 2.3 percent from last year, said IDC.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Chinese tech giant Lenovo, however, remained at the top of the market - owning more than 20% of it. HP followed in second place, with Dell third and Apple and ASUS tied for the fourth spot.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
6. Cancer Mortality Rate
Influenza neuraminidase: A druggable target for natural products
三大能源机构近期表示，今年石油输出国组织(Organization of the Petroleum Exporting Countries, 简称：欧佩克)以外国家的原油产量将增加，其中大部分来自美国的页岩油。除此之外，由于伊朗、伊拉克和利比亚可能会增产，中东地区的原油产量也许会增加数百万桶。所有这些势必会令油价承压。
The price of gold has risen 15 per cent since the beginning of 2017 to trade at $1,334.78 a troy ounce.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
“…started swearing during the interview.”
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.
So, what does that mean for oil prices in 2015? It is anybody’s guess, but here are the top five variables that will determine the trajectory of oil prices over the next 12 months, in no particular order.
Even if Gibson turns out to be a rental and leaves as a free agent this summer, the Thunder will likely feel good about these trade terms.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Everyone on Wall Street, Main Street and Washington keeps forgetting the fundamentals of market cycles. Please remember: Investors Business Daily's Bill O'Neill, author of 'How to Make Money in Stocks, ' says market cycles average 3.75 years up, nine months down.
Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
但是我们波士士顿波士顿咨询集团不认为中国本次改革会导致中国经济不稳定。我们相信中国经济在习主席的领导下会持续高速增长。我们相信上个星期的改革（三中全会）会确保中国经济从现在一直增长到（至少）2020年。根据我们已掌握的资料，我们预测中国经济在未来10年会增加4万亿美金(而书中说是6.4万亿。2012中国GDP为8.3万亿美金)。如果加上印度，亚洲两大国未来的增长总量会达到10万亿美金。在此期间，中产阶级会迅速膨胀，进而增强对经济增长的乐观态度。当然，没有人能完美地预测未来，在我们的近期的一本关于中国和印度经济发展的书中（《Trillion Prize:Captivating the Newly Affluent in China and India》），我们也描述了一些经济增长缓慢的例子。不过总体上我们还是对中国的未来保持乐观态度。
Inhibition of SARS coronavirus helicase by bismuth complexes
我在世界最知名的公司之一找到了一份工作，对此学校的关系网络起到了重要的作用，鹿特丹管理学院(Rotterdam School of Management)一名毕业生表示，这家公司是学校的一个公司合作伙伴，因此我基本上是在我的邮箱收到工作申请书的。
BROADCHURCH (BBC America, March 4) David Tennant returns in the second season of this evocative British mystery, playing Detective Alec Hardy again (after a season as Detective Emmett Carver in the American remake, “Gracepoint”). With the British premiere scheduled for Monday, the producers have begun to talk a little about the show’s top-secret Season 2 story line, and fans may not like what they hear: Chris Chibnall, the creator and writer, told a British magazine, “It’s not another crime case.” Olivia Colman returns as Detective Ellie Miller, while Charlotte Rampling and Marianne Jean-Baptiste join the cast.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
You've usually stated in pastinterviews that you have connections to your characters. In Aldnoah Zero, whichis currently airing, what do you think is your connection to Inaho?
"This is something we believe is really important for the future of our country,"Facebook (FB, Fortune 500) CEO Mark Zuckerberg said in August.
4. "The Big Bang Theory" (3.4 million)
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Slow growth around the world won't hurt the U.S. all that much. American exports might flatten out or even dip, but that would be offset by lower imports of petroleum because of sinking oil prices. So the trade deficit is unlikely to get further out of whack.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
10. 迪皮卡-帕度柯妮 1000万美元
The cemetery was found in the city of Kucha, which is located in present-day northwest China. Ten tombs were excavated, seven of which turned out to be large brick structures.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Average years of work experience: 11
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Always wanted to be an author but not sure where to start? Have you considered self-publishing? Thanks to Amazon, you can. Kindle Direct Publishing allows you to get the word out via e-books, CreateSpacehelps you develop a print edition and ACX is the audio publishing division. I’ve used all three to develop my book.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
5) I take a gloomy view of things 0 1 2 3 4
[娱乐时尚] Chanel,Now and Then 香奈儿的现在与
Russian President Vladimir Putin took a 10% pay cut last year, as his country sank into a deep recession. But that was after his salary more than doubled in April 2014, to roughly 9.7 million rubles.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
"It's a great conservation success story."
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
《危险！》(Jeopardy!)：这个游戏节目今年已播出50年（1964年3月30日首播），它证明自己不仅能难住观众，而且能令他们感到意外。不仅是因为主持人亚历克斯·特里贝克(Alex Trebek)留起了胡子（之前13年他都是把胡子剃得干干净净），而且是因为仍有些选手表明自己能刺激观众。今年刺激观众的是亚瑟·朱(Arthur Chu)，他采用闪电战式的答题方式，在网上引起一片哗然。他的策略令人兴奋，当然也很奏效：他在锦标赛中夺得第二名（友善的本·因格拉姆[Ben Ingram]最后得了第一）。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
法国的巴黎高等商学院(HEC Paris)和法国高等经济商业学院(Essec Business School)连续第三年分列第二和第三。
其他在定制课程排名中表现突出的学校包括哈佛商学院(Harvard Business School)，该院取得了今年最大幅度的排名攀升，上升9位至第5名。两年前，这所位于马萨诸塞州的学院还排在第18位。
贝克(Beck)，《说再见》(Say Goodbye)， Capito
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
With the second round of (re)negotiations closing on Tuesday we have truly entered the technocratic phase of these trade talks.
Bolder lawyers will start working with more “sci-fi” programs that claim to predict the outcomes of legal disputes before they have reached court, by analysing similar cases and past rulings, opposition tactics and win/lose statistics, the success rates of certain lawyers before certain judges, and so on.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Bobbi's dad Anton, 28, admits that he had his concerns at first, but is now comfortable with Bobbi's routine.
Vietnamese press claim chicken, sturgeon, fruit and vegetables from China have been undercutting local market prices. While illegal out-of-date produce is creating a black market in China.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Overall, live and recorded content achieved equal scores overall of 8.8 out of 10, while online interaction and team-work were rated marginally lower.
You can browse the full list at AskMen.com. Here are the top 10 women:
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The finest romance and the most acute anti-romance of the year, from some of the most rigorous intellects in American movies. The relationship between them is perhaps best summed up in this poem by William Blake, called “The Clod and the Pebble”:
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
With U.S. e-commerce activity approaching 10% of all retail sales, more merchants are shopping around for easy-to-use platforms that get them selling online quickly.
A modular microarray imaging system for highly specific COVID-19 antibody testing
This year, pop's best albums came from strong women who had a lot to say: Lorde's searing look at loneliness, Kesha's raucous statement of liberation, Taylor Swift's reckoning between her self and the version presented in the press.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
4. The 2012 Ig Nobel Neuroscience Prize
A hilarious video showed the swaying crowds singing Can’t Take My Eyes Off You and Hey Baby to the laughing young woman in Bordeaux.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
同时，美国Rapper歌手Eminem被证明是“复出王”，摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争，包括Drake, Future, Kendrick Lamar and Post Malone。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).
A facile assay for rapid detection of COVID-19 antibodies
Once the U.S. economic recovery started in 2009, other parts of the world started to struggle in their own ways.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Mr. Lyons took a casting of Ms. Swinton’s mouth and designed teeth to fit. Those were clipped on over Ms. Swinton’s real teeth. For Minister Mason, he came up with a quirky look but didn’t quite want it to be comical. He was, however, interested in adding a little bling. “There’s a little bit of gold on the left-hand side,” he said. “We used real gold to make the filling of one tooth. We did it to put more character into the character.”
Allow me to congratulate you on the arrival of the New Year and to extend to you all my best wishes for your perfect health and lasting prosperity.
The Asia-Pacific is the common home of all countries in the region. China does not want to see any party in the Asia-Pacific region feel compelled to choose sides under the influence of a Cold-War mentality.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Vegetable price growth more than doubled to 13 per cent year on year, helping push food inflation to 3 per cent, up from 2.7 per cent in September.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Statistics show global research and development expenditure grew at an annual pace of approximately seven percent before 2009, but slowed down to four percent in 2014
Guangzhou and Shenzhen, benefiting from balanced development, took first and second place respectively in the rankings. Hangzhou ranked third, owing to its technological advantages. Wuhan, which had achieved a good balance between development and costs, was in fourth place, followed by Nanjing with its quality culture and lifestyle.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Some of the biggest winners of the night included Lambert, Eric Church, Jason Aldean and Luke Bryan. Lambert led the pack with three wins for Female Vocalist of the Year, Single Record of the Year and Song of the Year for "Over You."
We will continue to encourage people to start businesses and make innovations.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The housing slump has cut demand for iron ore, energy and other commodities. Higher global supplies have exacerbated the gap between supply and demand and pushed raw materials prices lower. This dynamic is not expected to change in the near term despite measures such as the interest rate cut in November.
Length-scale dependence of protein hydration-shell density
"Shanghai has taken a series of tough measures to curb population growth since 2014, including renovating urban villages and regulating group renting," Zhou Haiwang, an expert with the Shanghai Academy of Social Sciences, told the Global Times.
People with near-perfect memories actually exist, and they have something called an "eidetic memory," which means they can recall a remarkable amount of information from their past experiences. Interestingly, many people assume having an eidetic memory means having a "perfect" memory, but even these superhuman memory machines can have some trouble recalling absolutely every detail with crystal clear accuracy. However, that doesn't mean you can't emulate these memory superstars and improve your own memory and protect yourself against age-related diseases and maladies.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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