Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Recipient: Britney Spears
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The central bank last year spent more than six months signaling its intent to wean the economy off a third round of bond-buying, and the prospect upset markets at just about every turn. Now it's only in the first stage of that process.
Americans: While you're here, why not pretend to be Canadian? Very few Britons can tell the difference, and it will allow you to rescue yourself from awkward conversations about the death penalty.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
18. 最有趣的道歉（并列）。11月18日，《好莱坞报道者》发表了一份1200多字的道歉，因为它的“奥斯卡女星圆桌会议”没有邀请非白人演员出席。很快，导演亚历克斯·普罗亚斯(Alex Proyas)和狮门公司就为新片《埃及众神战》(Gods of Egypt)中的演员缺乏多样性而道歉。
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
No, this doesn't mean you should abandon your LinkedIn profile for fear of a suspicious boss. But it does mean you should be more careful. For one, turn off your activity broadcasts so that every savvy move you make isn't announced to your entire network. Here's how: From the homepage, hover over your photo in the top right corner, and click on "Privacy & Settings." From this page, click "Turn on/off your activity broadcasts."
Explaining how he adjusted the novel, he said: 'I think the answer is that in the book I remain true to every one of Bond's things.
Trends and targets in antiviral phototherapy
MasterCard says its index reflects the interconnectedness of major global cities and tracks the ways in which business and leisure jet-setters spend their money.
The questions can seem like a sudden reversal after decades of rising multiculturalism, through the civil rights movement in the United States and the European Union’s opening up of borders.
●"Pope Francis Shocks World, Endorses Donald Trump for President, Releases Statement"
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
A Honda executive privately attributed much of its troubles on “bad luck,” as opposed to shoddy business practices or deliberate misbehavior on anyone’s part. Perhaps. The company’s leadership is certain to check, double-check and lock down its systems and processes to ensure the level sinks no lower on its reservoir of good will.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The Shape of Water
ACE2 as a potential therapeutic target for pandemic COVID-19
The US remains home to the biggest brands and the value of its top 10 increased by 10 per cent to $1.3tn in 2016. The top 10 UK brands, headed by Vodafone, lost 8 per cent of their value. Those in continental Europe — led by Germany’s SAP software group — rose 5 per cent. Finally, the $360bn value of Asia’s top 10 brands, headed by Tencent, China Mobile and Alibaba, was only 10 per cent lower than the value of the top 10 in continental Europe and the UK combined.
Diagnostic technologies for COVID-19: a review
朱克斯提醒，我们目前正处于第四次超级大泡沫之中，它是美联储在保守经济学兴起以来的30年时间里吹起来的。他将这个泡沫称为“暂时没有名字的泡沫”(Bubble With No Name Yet)。好，大家来给这个新泡沫命名吧。但不管你叫它什么，都要快点起名，因为它马上就要爆了，就像过去30年相继破灭的亚洲泡沫、互联网泡沫和信贷泡沫一样。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
考夫曼和同事加雷思?哈里斯(Gareth Harris)发现，居住在那些人种快速多样化地域的英国白人更倾向于投给右翼的英国国家党(British National Party)。宾夕法尼亚大学政治学教授丹尼尔?霍普金斯(Daniel Hopkins)在美国发现了相似的民族变化导致反移民政策的规律。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
尽管法国和西班牙的商学院在“无工作经验要求”项目排行榜上位居前列，但英国商学院才是该榜单的真正“大户”，50所上榜商学院中有17所是英国的，领先于美国（8所）和法国（6所）。两所英国商学院——伦敦商学院和剑桥大学(University of Cambridge)贾奇商学院(Judge Business School)——在“有工作经验要求”项目排行榜上领跑。
Goldie Blox is a toy company on a mission to redefine the “pink aisle” in toy stores. Men dramatically outnumber women in science, technology, engineering and math (STEM) education and careers, with girls largely losing interest in these topics by age 8. Goldie Blox toys are designed to inspire future engineers by engaging girls in a way that draws on their strong verbal and storytelling skills — while still offering opportunities to build the skills that can later translate into an interest in engineering. And speaking of opportunity, how does a start-up toy company stand out against the big names that have been dominating the toy space since the beginning of time? In a savvy move, Goldie Blox recently released a video that went viral with their take on the Beastie Boys song “Girls.” Though the video was ultimately taken down, Goldie Blox did an excellent job raising awareness of the need to get more women and girls interested in STEM … and of the Goldie Blox toys.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The next big attempt at a global climate agreement will come when negotiators from around the world gather in Paris in December. Political activists on climate change wasted no time Friday in citing the 2014 heat record as proof that strong action was needed.
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
The number of students who will study abroad after graduation has also seen a drop, down from 4.8 percent last year to 3.4 percent.
1. Hokkaido, Japan-Though known primarily to the outside world for its ski resorts and powdery snow, Hokkaido's year-round beauty might soon become a more familiar sight to foreign visitors. The new bullet-train service from Tokyo should help.
Angela Merkel's salary as German chancellor is set at 218,400 euros a year ($242,000). The chancellor got a 2% pay rise at the beginning of March, and will get another 2% next February.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
It grows naturally into the mold's shape.
The role of biosensors in the detection of emerging infectious diseases
3. Jeonju, South Korea-Hundreds of traditional Korean houses remain in central Jeonju's Hanok village.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
4. Jennifer Aniston - $21 million
Format: Classes meet every other week from Friday through Sunday in Evanston, IL, or once a month from Thursday afternoon through Sunday noon in Miami, FL
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
As we ring in the New Year, let’s take stock of where we are at with the oil markets. 2014 proved to be a momentous one for the oil markets, having seen prices cut in half in just six months.
According to a notice jointly issued by the Ministry of Human Resources and Social Security and the Ministry of Finance, the average monthly payments for both enterprise and institution retirees will be increased by about 5.5% from the 2016 level.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“It is an area where clearly the fundamentals are slowing down,” he says. “I sold down a little bit, then the whole correction happened very quickly, so I waited for a rebound and sold there.”
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Recipient: Lindsay Lohan
Best Luxury Brand: Porsche
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
IMD participants praised the way their training pushed them out of their comfort zones and also the one-on-one coaching sessions tailored to their individual business situations. “It was an eye opener about what a good leader is,” commented one participant. “We learnt about ourselves first, what drives us and why, in order to manage others.”
In January, Wal-Mart (WMT, Fortune 500) U.S. president And CEO Bill Simon pledged that the world's largest retailer would hire 100,000 veterans over the next five years. In addition, the biggest private employer in the U.S. said it would offer employment to any honorably discharged veteran within his or her first 12 months off active duty.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
All those totals are higher than a year ago, with the largest growth being in market value (up 13% year-over-year). These firms employ 90 million people worldwide.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
宾夕法尼亚州圣约瑟夫大学(Saint Joseph’s University)的Haub商学院(Haub School of Business)是唯一一所首次上榜的学院，排在第98位。
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The Female Warlord Who Had C.I.A. Connections and Opium Routes
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
This year, China will further enhance international cooperation in fighting corruption, said a statement adopted at the second plenary session of the 19th CPC Central Commission for Discipline Inspection.
全球新职介绍公司Challenger Gray & Christmas 的执行总裁John Challenger 说：“经济不景气之后，总会有个就业复苏期，但是我们的确对2010年的就业率不抱多少乐观态度。”
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Additional reporting by Ma Nan
Wealthy Chinese are showing growing interest in islands in recent years.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
It was last above 50 - the threshold separating contraction from expansion - in February.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Do you often feel gloomy and down in the dumps?
British schools outperform the French on both new criteria. Warwick Business School, the top UK school for career progress, is second overall for the criterion, 30 places above the first French school, HEC Paris. Alumni from UK schools also see a higher increase between their first salary after graduation and now, at 62 per cent versus 45 per cent. However, UK school alumni still have a lower salary on average than their counterparts who studied in France, at $55,000 versus $64,000.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
John Stevenage, chief executive of British Mensa, said he was delighted for Nishi. He said: 'I hope she will make full use of her membership to meet new, like-minded people and challenge herself. Joining Mensa opens the door to an international network of more than 100,000 people and many members make friends for life.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
要让Airbnb退市，可能没那么容易。最近，昆尼皮亚克大学(Quinnipiac)开展的一项民意调查表明，56％的受访者认为，应该允许纽约人将房间租给陌生人。“我们不想把房子变成旅馆，但是与此同时，人们有时会想把自己的公寓租出去。”霍尔斯特德管理公司(Halstead Management Company)的总裁保罗·R·戈特塞根(Paul R. Gottsegen)说。该公司打理着纽约市250处住宅物业。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
They're the top three most unaffordable housing markets in the world, according to the 13th Annual Demographia International Housing Affordability Survey: 2017, published recently.
James Bond Themes 5. "Live and Let Die" by Paul McCartney and Wings
The total number of qualified applicants reached 31,220 in the first 24 hours, up from 25,000 over the same period last year, according to figures from offcn.com, an education organization that offers training for the civil servant exam.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Insead is distinguished not only by its one-year programme but also a strongly international culture, based upon its two campuses, and one of the most extensive and diverse alumni networks. The programme is ranked third for the international mobility of its alumni and sixth for international course experience.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
5.Branding: 16.4 percent increase
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Security questions risks
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
In addition, the 1980 stamps were designed by Huang Yongyu, 92, a well-known Chinese master painter, making it a collectible item with extreme value.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
NeXT 电脑公司总裁兼CEO史蒂夫乔布斯在向公众展示他的新一代NeXT 工作站（此时乔布斯已经离开苹果创办了皮克斯动画和NeXT 电脑公司），1990年9月18日，旧金山
The January-to-November period in the United States this year was the warmest first 11 months of any year on record for the contiguous states. And 2012 will likely surpass 1998 as the warmest year on record for the nation, according to the National Oceanic and Atmospheric Administration.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Skyfall Bond girl Berenice Marlohe has joined the all-star cast of Terrence Malick’s latest movie, which is in production in Austin.
For all of the acceptance speech kerfuffle when Gwyneth Paltrow won best actress for her role as Viola de Lesseps in John Madden’s 1998 film Shakespeare in Love, the Hollywood star has since said she keeps the award tucked away – “the thing freaks me out”.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Paul George, Chris Paul, Carmelo Anthony, Gordon Hayward Jimmy Butler, Derrick Rose, Paul Millsap, J.J. Redick, Eric Bledsoe, Dwight Howard ... the list goes on and on of players who switched uniforms since last year.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Tumor Biology, a journal published by Springer Nature, announced last week that it had retracted the papers after an investigation showed the peer review process had been compromised.
1.The Military Parade
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
在所有这些影片中，斯文顿用的是同一个牙齿设计专家——伦敦Fangs F/X公司的克里斯·莱昂斯(Chris Lyons)。他在工作中设计了各种牙齿，包括为坎耶·韦斯特(Kanye West)一个音乐录影带中的一只杜宾犬设计了金色尖牙。
Also featured in the 2013 top 10 were Singapore, Zurich, Paris, the Venezuelan capital of Caracas and Geneva.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
3.Pay no attention to those bow-tied etiquette experts you sometimes see on CNN International, telling you how to behave while in Britain. These people are generally of dubious provenance, normally live in California and tend to peddle advice that is either irrelevant or out of date. For example, they will often say that Britons love queuing and are so fond of apologising that they will often say "sorry" even when something isn't their fault. In reality, Britons are just as likely to jump to the front of a queue and then punch the person behind them for coughing. It all depends on how muggy it is.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
With most of our favorite shows on or approaching the dreaded holiday hiatus, it's time to reflect on the women that made the fall 2011 TV season so great.
Judge for yourself.
Length-scale dependence of protein hydration-shell density
Dachis says: The news just keeps getting worse for Mitsubishi. Low sales triggered a decision to pull out of the European market and if the levels of negative discussion are any indicator, 2013 doesn’t look to be any better.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
1. “Timbuktu”(Abderrahmane Sissako)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
In 2017, his 14th season in the league, LeBron James averaged a career high in assists and rebounds. In the first two months of 2017-18, he's averaging a career high in 3-point percentage, but that's been talked about and dissected; it's been written about extensively.
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over $50,000 category, pickups and SUVs distributed through non-premium dealers outsell German luxury brands.