Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Pork prices, which are heavily weighted in the food-focused basket of goods used to calculate consumer inflation, rose 4.8 per cent.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
And the best gig for 2015? That would be an actuary, the people who specialize in financial risk.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Seoul insists the activists have a democratic right to send the leaflets, but has appealed for restraint to avoid overly provoking the North.
Trends and targets in antiviral phototherapy
The number of people holding degrees from colleges or universities reached 170.93m, which means there were 12,445 people with an advanced education per 100,000 people in 2015, up from 8,930 in 2010. The number of people who had attended a senior high school also increased, and the number who had only completed lower-level education fell.
If you have a question, come to my office. Don't corner me in the bathroom.
The contiguous United States set a temperature record in 2012, a year of scorching heat waves and drought. But, mostly because of the unusual chill in the East, 2014 was only the 34th warmest year on record for the lower 48 states.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The U.S. Veterans Day holiday also coincides with other World War One-era holidays around the world, including Remembrance Day in Britain and the Commonwealth nations of Australia and Canada.
Novel biosensing methodologies for ultrasensitive detection of viruses
Beck “Say Goodbye” (Capitol)
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
However, some lawmakers already are discussing a standoff again in late February over raising the federal borrowing limit. 'You can never count on policy makers to not shoot themselves in the foot,' Mr. Daco said.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
According to the China Auto Dealers Chamber of Commerce, which is helping to organise the dealers, Hyundai’s import-only dealer network has already halved in size since 2014.
有些热门剧已经走得太远，应该降降温了，却仍在大张旗鼓，比如《唐顿庄园》(Downton Abbey)、《丑闻》(Scandal)和《复仇》(Revenge)。ABC频道的新剧《逍遥法外》(How to Get Away With Murder)是一部有趣的替代品，它是一部耸人听闻的夜间肥皂剧，讲述不法辩护律师的故事，简直可以称为“法律与无序”。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
While D'Aloisio spends 80 percent of his work time retooling and improving Summly (which has already been integrated into Yahoo!'s iPhone app), the other 20 percent is devoted to imagining the expansive challenges he'll take on next. He predicts there will be summarization programs that do for video what Summly does for the written word. He has grand thoughts about using technology to aid learning and would like to help fellow autodidacts while disrupting the old educational models.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
China's Booming Cyberstar Economy Might Hit $8.7b in 2016
8. Smile every time EXCEPT when my team is losing.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
Throughout Downsizing, I kept asking myself what the point of all of this was, never engaged by its hodgepodge of themes. I wish the filmmakers had asked that question too.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Others are Ouyeel, a unit of Shanghai Baosteel Group that provides financing for steel traders; and Small Entrepreneur, part of China Merchants Bank — the country’s sixth-largest lender — which focuses on wealth management.
Anyway, it's nice to see that LeBron has filled into his monster physique nicely in the past nine years.
The role of biosensors in the detection of emerging infectious diseases
The Republican candidate appeared unsure at times and occasionally stumbled over his lines as if struggling to remember his briefing notes. He began sweating as Obama, aggressive from the start, got the better of him during exchanges on Iran, Iraq and Russia as well as on US military spending.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
TextPride changed its name to Swyft Media and launched a platform that pushes emojis and stickers from new brands into messaging apps. Brands pay for the privilege, as they would with a regular ad campaign.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
15. An Amazing Coincidence One of the studios with the most on-screen diversity — it released “Trainwreck” and “Straight Outta Compton” (if also “Ted 2”) — and with the most female directors is Universal, which, as of early December, had gobbled up almost 24 percent of the year’s market share.
In an explanation released alongside the latest data, the statistics bureau credited ongoing growth in producer prices in part to coal extraction and washing prices, up 15.4 per cent for the period and accelerating 11.3 percentage points from a month earlier.
Musk said he expects to be producing cars at a 100,000-a-year rate by the end of 2015.
Swyft now makes half of its money from ad campaigns like the one for Gwen Stefani. Swyft’s revenue has increased between 50% and 100% each month, Wray says. The other half comes from selling stickers—typically licensed from sports teams and entertainment brands like Shrek.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
1. Bottoms Up Beer System
So take a look. I sincerely hope you enjoy reading them as much as I liked selecting and editing them.
The January-to-November period in the United States this year was the warmest first 11 months of any year on record for the contiguous states. And 2012 will likely surpass 1998 as the warmest year on record for the nation, according to the National Oceanic and Atmospheric Administration.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
“只要总体市场仍然相对积极，只要交易继续执行良好，我们继续预期今年余下时间会保持健康的交易量，”高盛(Goldman Sachs)美洲股票资本市场主管戴维?路德维格(David Ludwig)表示。
The UK’s Warwick Business School recorded the best progression at the top, moving up from 16th to ninth place, while the Shanghai Advanced Institute of Finance (Saif), based at JiaoTong University, enjoys the bestprogression overall, jumping from 28th to 14th place.
Inhibition of SARS coronavirus helicase by bismuth complexes
This slide in the dollar value of exports has entirely been a price effect, driven by lower commodity prices. In volume terms, emerging market exports have continued to rise since 2014, even if volume growth in year-on-year terms has moderated to around 2 per cent, a fraction of the double-digit rates witnessed either side of the global financial crisis, as the second chart shows.
I'm not worried about Philly, Phoenix, or Minnesota. They're young, they're rebuilding. If they make strides, great. If not, take another high pick. The Nets are the Nets and we should talk about them in a minute.
Average age: 33 in Philadelphia, 36 in San Francisco
For many Western whites, opportunities for achieved identity — the top of the hill — seem unattainable. So their ascribed identity — their whiteness — feels more important than ever.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
8.The Big Bang Theory Whiteboard Has Real Equations
Stallone's iconic underdog has spent decades inspiring athletes and nonathletes alike to fight for their goals. As a poor local boxer, Rocky gets his break when he enters a fight with World Heavyweight Champion Apollo Creed. Due to his rigorous training and Creed's relative apathy, Rocky becomes the first challenger to ever push Creed through all 15 rounds.
“Even though I’m an engineer and an analytical person at heart, the most important decisions I’ve ever made had nothing to do with any of that,” he told an interviewer at Duke University, where he studied for an MBA, last year. “They were always based on intuition.”
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
China's movie box office revenue rose 13.45 percent in 2017 to more than 55.9 billion yuan (8.6 billion U.S. dollars), with domestic films contributing 53.84 percent to the market, according to the State Administration of Press, Publication, Radio, Film and Television.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
You qualify as a type D personality if you scored 10 or higher on both Negative Affectivity and Social Inhibition scales.
If it isn't appropriate to interrupt, make a quick note of your question so you don't forget, and ask later.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The ranking rates the best 100 programmes worldwide for working senior executives.
The 1.48 million people who qualified to take the exam marked an increase of 90,000 over last year, while the number of positions offered - 27,000 - remained almost the same.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The report noted that 201 million people or 27 percent of Internet users were from rural areas, or a gap of 45.2 percent in the Internet penetration rate between urban and rural areas.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Barrymore's condition was based on the real life of Michelle Philpots, who suffered head trauma in two separate motor vehicle accidents, which left her with a 24-hour memory. Rather than using Sandler's tapes, Philpots has survived for over 23 years using Post-it notes and her (amazingly modern, from her perspective) mobile phone.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
"I'm not really worried about it, honestly," Bryant said. "My shooting will be better."
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Harvard Business School, London Business School (LBS) and MIT Sloan School of Management, three of the MBA ranking’s longstanding heavyweights, all lost ground to their competitors. Harvard drops two places to fourth, the first time in nine years that the Boston school has been outside the top three. London Business School falls three places to sixth, its lowest position in 14 years. MIT Sloan School of Management falls to 13th place, the first time in 10 years that it has been outside the top 10.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
One highlight of last year's box office was seven high-quality domestic films listed on the top 10 earners, including 'Monster Hunt', a live-action hybrid, and 'Monkey King: Hero is Back', a 3D animation based on the classic ancient story.
We've had the technology to artificially restore hearing for decades, but internal implants do nothing for the visible parts of the ear. You'd think those big flaps (“pinnae”) on either side of your head would be easy to replicate, since they're just skin and cartilage rather than complex organs. In reality, scientists have never done a good job with fake ears. Traditional replacements look and feel like plastic toys.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Oops. Better luck in 2015, everybody.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
But the young boy still had on last trick up his sleeve before surrendering.
"It may affect them for life," Dershowitz said.
Mr Karl added: “We would have likely had a record [year] even without El , but it pushed it way over the top.”
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
How do you feel about workingwith Ei Aoki again in Aldnoah?
Institutions may also fail.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Among the 18 sectors categorized by the China Securities Regulatory Commission, financial executives ranked the highest with annual pay of 27.36 million yuan, followed by real estate executives at 11.18 million yuan.
Add your scores for 10 to 14 to find out how you score on the Social Inhibition scale.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."
‘The Good Wife’ Once Will (Josh Charles), Alicia’s illicit love interest, died at the end of Season 5, this sexy CBS courtroom drama seemed as if it might droop and wither, but instead, the sixth season steamed with almost madcap energy, mixing Alicia’s newly fledged political campaign, a war of the roses between Alicia’s new firm and her old one, and the legal travails of Cary, her legal partner. Alicia isn’t quite so good anymore, and that makes “The Good Wife” all the better.
A modular microarray imaging system for highly specific COVID-19 antibody testing
As the unstoppable Nazi forces roll across Western Europe and the threat of invasion is imminent, and with an unprepared public, a skeptical King, and his own party plotting against him, Churchill must withstand his darkest hour, rally a nation, and attempt to change the course of world history.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Global pharmaceutical spending will surpassthe trillion dollar threshold in 2014, with high prices for innovativehepatitis C and cancer drugs in the US, a new study says. By 2018spending is expected to increase by another 30 percent.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The strategy of Four comprehensives: Comprehensively building a moderately prosperous society, comprehensively driving reform to a deeper level, comprehensively governing the country in accordance with the law, and comprehensively enforcing strict Party discipline
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The raised decoration shows a cartouche — an oval frame around Egyptian hieroglyphics indicating a royal name. Above the frame archaeologists could make out the symbol of an eye and that of a cobra.
It is an acoustic guitar-led anthem and instant lighters-up classic, pivoting into punk-pop with Eagles of Death Metal on "Let 'Em Talk".
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The show airs on CBS December 4.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
At its own auction the following evening, Sotheby’s achieved a far more respectable total of 22.6 million with fees, although it was just above the low estimate of 21.8 million based on hammer prices. Of the 44 lots offered, 15 did not sell, or 34 percent.
Take targeted policies to cut excess urban real estate inventory
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
BROAD CITY (Comedy Central, Jan. 14) Ilana Glazer and Abbi Jacobson return for a second season of satirizing the poses, compromises and sheer physical grossness of life in New York when you’re underemployed and self-absorbed.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The announcement comes from the British Fashion Council (BFC), who surveyed designers ahead of the shows and found none of the 80 designers in the September line-up would be using fur.
The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The United Kingdom ranks No. 3 overall. It ranks No. 4 in Power and No. 5 in Cultural Influence.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Marcos Carvalho, an 18-year-old Brazilian fan who was hanging out near the Estadio Nacional in Brasilia before Brazil played Cameroon earlier this week, said that he "didn't even try getting tickets, they were too expensive.""There was no way we could afford them," he said. "We'll just watch the match at home, it's all we can do. We are seeing everyone going to the stadium, everyone happy, but we won't be going."
Anti-HIV drug repurposing against SARS-CoV-2
May the New Year be a time of laughter and real enjoyment for you. Best wishes.愿新年不仅是你欢笑的时刻，更是你欣喜的日子。祝福你。
Length-scale dependence of protein hydration-shell density
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
在MBA榜单上，伦敦商学院、INSEAD和西班牙企业商学院(IE Business School)毕业生的薪酬相差无几，只有几美元的差距。INSEAD的毕业生薪资最高，为15.5015万美元。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
China will remain an important engine for world growth amid sluggish global economic recovery.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
《副总统》(Veep)：Netflix公司的热门剧《纸牌屋》(House of Cards)今年露出疲态，但另一部讽刺华盛顿的HBO电视剧《副总统》却在第三季中更上一层楼。塞琳娜（朱莉娅·路易斯-德莱弗斯[Julia Louis-Dreyfus]饰）和助手加里（Gary，托尼·黑尔[Tony Hale]饰）在洗手间里发现自己即将成为总统后，激动得失声大笑，成为2014年喜剧片中最滑稽的一幕。