Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The director Bennett Miller saw Mr. Carell as a good choice to play du Pont but didn’t want him to be too recognizable. He charged the makeup designer Bill Corso with the task of altering Mr. Carell’s look.
Anti-dumping cases were much easier to bring in the US than in the EU where companies first had to pass a public interest test.
Trends and targets in antiviral phototherapy
What growth dollar exports did see among major trading partners came from shipments to the US, which rose 5.5 per cent year on year to $37.06bn. Exports to South Korea also showed growth of 8.3 per cent to $10.2bn.
Entrepreneurs are movers and shakers. They can’t afford to analyze every detail or they’d never get anywhere. There is no place for procrastination in a startup. It’s a 24/7, no-vacation-or-sick-days kind of job that demands constant forward momentum. Make a brief assessment at every step and move on it. Trust your instincts.
You're right to be paranoid. The company is always watching you, and there's a record of everything you do: every phone call, every text, every tweet and instant message. At most companies, they save that data forever.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
"As a native of Shaanxi, I found Sun played the role well. She jumps and runs wildly, just like a typical young naughty Shaanxi girl," a netizen Xuelili said.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
China has 731 million Internet users as of December 2016, roughly the size of Europe's population, according to a report released by the China Internet Network Information Center (CNNIC).
ACE2 as a potential therapeutic target for pandemic COVID-19
China’s investment in Europe and the US has reached record highs, despite the slowdown in the country’s domestic economy.
Diagnostic technologies for COVID-19: a review
Lawrence Yun, the trade group's chief economist, expects the average 30-year fixed-rate mortgage to hit 5.5% at year-end, up from 4.5% late last year and 3.5% in the first half of 2013. That's a sharp runup in a short period of time, one that could harm affordability and spook even more buyers.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
"Metro-Goldwyn-Mayer Inc. ('MGM') today announced that the secured lenders voting in the Company's solicitation process have overwhelmingly approved its proposed plan of reorganization ('Plan'). MGM will now move expeditiously to implement that Plan, which will dramatically reduce its debt load and put the Company in a strong position to execute its business strategy. MGM is appreciative of the lenders' support."
6.Miniature Human Brains
? Aid workers are worried about a food crisis in Haiti, where Hurricane Sandy killed 52 people last week. The UN is also concerned that flooding could lead to a sharp rise in cholera cases. At least 69 people were killed by Sandy in the Caribbean.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
She said: 'Mom is like, "Oh my God, let's go and meet Ariana Grande." I'm like, "Mom, for real?"
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The average entrepreneur uses dozens of cloud-based software and apps. Zapier connects your online life and helps you build new functionality. The best part about Zapier is that you don’t have to be an API wizard to use it.
A separate Caixin PMI tracking growth in China’s services sector is slated for release on Tuesday.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
The theory describes Type B individuals as a contrast to those of Type A. Type B personality, by definition, are noted to live at lower stress levels. They typically work steadily, and may enjoy achievement, although they have a greater tendency to disregard physical or mental stress when they do not achieve.
According to figures from Zhonggong Education, an institute that monitors the applicant numbers, more than 459,600 people applied to take the exam by the sixth day of this year's application window on Tuesday. Almost 103,000 of those had applied on Monday.
Still, experts see a crisis of white identity underlying much of the West’s current turmoil.
Most successful entrepreneurs follow comparable patterns and share similar basic characteristics. Hundreds of online articles and published books claim to know the secret of success in business, but for the most part, they boil down to the same major points.
Influenza neuraminidase: A druggable target for natural products
I know this takes time, but it'll ensure you really know your stuff. And that's why you're going to school. Right?
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Microsoft Corp., Toyota Motor Corp., IBM Corp., Samsung Electronics Co. Ltd., Amazon.com Inc., Mercedes-Benz and General Electric Co. were also on the Top 10 list, according to Interbrand's 2016 Best Global Brands report.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Perhaps just as important, stable or falling prices will boost the inflation-adjusted pay of U.S. workers and gives them more bang for their buck. "It's an unambiguous positive for household demand," said Neil Dutta, head of economics at Renaissance Macro Research. "People will have more money to spend."
Liu Fei was also a half-brother of the Emperor Wu of Han who ruled from 141BC to 97BC.
萨默塞特?毛姆（Somerset Maugham）曾形容法国里维埃拉（French Rivier）为“阴暗人物的阳光之地”。环视着酒店大堂里的“模特”，带着黑超的男人们似乎与他们相识，我似乎理解了毛姆。戛纳华丽的外表下有着其并不光彩的一面，就如湛蓝的海水下垃圾成堆。电影节开幕前，法国潜水员，同时也是环保人士的Laurent Lombard(劳伦?隆巴德)拍摄的戛纳河床沉积着大量垃圾废物的视频被疯传。我们被告知在此游泳并无危险。据《每日邮报》报道，市长已下令清理。但是小镇确实不再那么闪耀迷人了。
8. You left your résumé in the freaking printer!
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
当你听说今年3月份，一个17岁的学生把自己设计的一款软件以3,000万美元卖给雅虎公司(Yahoo! Inc., YHOO)的时候。对于这孩子的形貌，你脑海里或许已勾画出一个搞笑的形象了吧：不用说，肯定是个极客。一个除了一行一行写代码之外对什么也不感兴趣的学霸。一个不敢正眼瞧人还老小声儿嘀咕着什么的神经质。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
"The autonomous region has invested 4 billion yuan (around 600 million US dollars) to promote industries with local features in poor areas, and relocated 77,000 poor people last year," said Lu Huadong, deputy director with the office.
Inhibition of SARS coronavirus helicase by bismuth complexes
2. The Hammocraft
The Disaster Artist is part buddy movie, part show-business fable, and part behind-the-scenes DVD featurette.
Kate Hudson spoke to British Elle magazine exclusively for this interview。 凯特·哈德森接受了英国ELLE杂志对她的独家专访。Does actress Kate Hudson know wha
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.
2. Dominos. Brand love: -11% / Rank: 62
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
v. 商讨，向 ... 请教，查阅
At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
You can read the full list of stories, but here are the top five:
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
More advanced components are in short supply, however, which could leave many customers waiting long after September to get hold of the new iPhone. That presents an opportunity for rivals such as Samsung’s new Note 8 or Essential, the smartphone maker led by Android co-founder Andy Rubin, which is targeting premium customers such as Apple’s with its slick $699 device. Google is also said to be preparing a new version of its Pixel smartphone, which has proved popular with early adopters.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
2. Worldwide Murders
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The movies were selected from more than 2,000 titles from 100 countries and will be screened in 30 cinemas and colleges around Beijing from April 8 to April 23, Zhang Xiaoguang, deputy head of China Film Archive, said last Thursday.
《初来乍到》(Fresh off the Boat)，ABC，2月4日播出。这部喜剧是根据大厨与美食、旅游真人秀主持人黄颐铭的回忆录改编的，讲述20世纪90年代中期的佛罗里达，一个华裔美国家庭克服文化冲突，努力适应美国生活的故事。哈德逊·杨(Hudson Yang)饰演迷恋嘻哈乐的11岁男孩艾迪，在《采访》(The Interview)中饰演金正恩的兰道尔·朴(Randall Park)饰演他的父亲，一位郊区牛排餐厅骄傲的店主。
Wishing you all the happiness of the holiday season.祝节日幸福如意。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Written instructions apparently issued by China’s tourism administration, shown to the FT by one Beijing travel agent, order agencies to cancel group tours to South Korea booked for after March 15 and add that companies not in compliance could be fined or have their licences revoked. The tourism administration was not immediately available for comment.
He slipped a note through the door with the message "People stuck inside, please ask the property management for help," and hoped someone would pick it up and act on it.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
As computer programming is being hailed as the untapped opportunity in the American economy, New York Code and Design Academy is making it easier to speak code. By 2020 there will be 1.5 million computer science jobs with only 400, 000 computer science graduates. Moreover, computer science jobs are growing at twice the national average as other positions. But what if you didn’t graduate with a computer science degree, and have no plans to go back to college? New York Code and Design Academy is making it easier to learn web design and development by offering both night programs and intensive workshops — where it’s not uncommon for someone to walk out of the program having built a new website or setting sights on a new tech-based position at work. From where Founder Jeremy Snepar sits, you can’t afford to not know how to code in today’s digital economy. He sees coding as a technical skill that can and should be easier to learn, and New York Code and Design Academy is filling an important gap for anyone who’s ever said “if only I knew how to code.”
Turkey dance “Fire” (Fire of Anatolia)
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
7.M·A·S·H Star Never Signed his Contract
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Ellen is a stand-up comedian and is best known for her self titled talk show, which she's hosted since 2003.
The next big attempt at a global climate agreement will come when negotiators from around the world gather in Paris in December. Political activists on climate change wasted no time Friday in citing the 2014 heat record as proof that strong action was needed.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
This makes China the leader among middle-income economies for this indicator, followed by India which has overtaken Brazil, according to the report jointly released by Cornell University, INSEAD and the World Intellectual Property Organization (WIPO).
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
在主张对华强硬的史蒂夫?班农(Steve Bannon)出局之后，人们就忍不住想要宣布特朗普政府的经济民族主义已死。但这忽视了唐纳德?特朗普(Donald Trump)是怎样一个人——他是一个本能的保护主义者。正如我们近来所了解到的，对于中国，他更想要的是“关税”而不是交易。他还认为打击中国是向其基础选民履行他的“美国优先”承诺的关键。
SAN JUAN, Puerto Rico (AP) — Puerto Rico’s new governor was sworn in Monday as the U.S. territory prepares for what many believe will be new austerity measures and a renewed push for statehood to haul the island out of a deep economic crisis.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
9. Putting Yourself in Someone Else's Shoes Improves Memory
"Hong Kong is a small island with 7 million people ... and you have 1.5 billion across the border (in mainland China) who would like to invest," Mark Elliott, associate director of International Residential Property Services at Jones Lang LaSalle, tells CNN. "The government is releasing more and more land, but it doesn't work."
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Here, you may be delegates of your governments, business people, organisers, reporters or poiticians - but really you are mothers and fathers, brothers and sister, aunts and uncles - and all of you are somebody's child. 在这里，您可能是您政府商业人士的代表、组织者、记者或政客。但您们也是父亲和母亲、兄弟和姐妹、阿姨和叔叔，你们都会或多或少的为了下一代而活着。
3. Your boss received your résumé from a contact of a contact。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
"You're part of the past, but now you're the future," Lana Del Rey sings on Lust for Life's opening track, "Love".
I have never ordered an ice bucket for my red wine. In fact, come to think of it, I have never ordered an ice bucket for white wine, Champagne or dessert wine.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
贝尼托.墨索里尼(Benito Mussolini)和阿道夫.希特勒(Adolf Hitler)就是煽动家变身独裁者的经典例子。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
John Williams's classic score still raises goosebumps over 40 years after this summer blockbuster hit theaters. Jaws preys on our primal fear of the unknown in deep waters, showing a small beach town ravaged by a series of attacks from a single killer shark. In recent years, environmentalists have stressed the generally nonthreatening nature of sharks, which kill an average of just eight swimmers each year.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Apple CEO Tim Cook
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Suspecting that the water had been mixed with something harmful, Tang reported the incident to the class monitor and teachers.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Now that Chris and his girlfriend, Rose, have reached the meet-the-parents milestone of dating, she invites him for a weekend getaway upstate with Missy and Dean. At first, Chris reads the family's overly accommodating behavior as nervous attempts to deal with their daughter's interracial relationship, but as the weekend progresses, a series of increasingly disturbing discoveries lead him to a truth that he never could have imagined.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Length of program: 19 months
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The U.S. Congress and the media will go berserk when Goldman announces the size of its 2009 bonus pool. But the outrage will be brief and of little lasting consequence. The 'hate Goldman Sachs' story has been running just too long.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
“One person had his wife call to tell his boss he was not coming back.”
Anti-HIV drug repurposing against SARS-CoV-2
Like many child stars, Maddie speaks of being old before her time.
3. 《间谍之桥》(Bridge of Spies)。几年前，史蒂文·斯皮尔伯格(Steven Spielberg)进入了殿堂级导演的行列，从安德鲁·萨里斯(Andrew Sarris)所谓的“美国电影”中借鉴了最崇高的形式——这部影片中他仍然保持水准。
Length-scale dependence of protein hydration-shell density
The spread of HIV through drug injections has been effectively controlled. In 2017, the number of people infected through drug abuse was 44.5 percent lower than that in 2012.
9.Yeah, I was a badass on my high school football team! – Because I want to be seen by others in an even stronger light than I see myself。
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
总部位于芝加哥的竞争对手科尔尼(AT Kearney)也在为领导层变动做准备，计划于2018年第一季度投票决定接替约翰奥利格(Johan Aurik)的人选。管理合伙人最多担任两个任期，而奥利格已经期满。预计他的继任者将专注于让科尔尼做大，摆脱中等规模参与者之列。
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
As the unstoppable Nazi forces roll across Western Europe and the threat of invasion is imminent, and with an unprepared public, a skeptical King, and his own party plotting against him, Churchill must withstand his darkest hour, rally a nation, and attempt to change the course of world history.
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Over the past 20 years, at least 133,000 units in the city have gone market rate because of this rule, according to the Rent Guidelines Board. If the trend continues, rent stabilization could be further weakened, undermining Mayor de Blasio’s efforts to preserve affordable housing, say supporters of the policy.
Cullinan and Ruiz each carry a suitcase containing a copy of the winning envelope for all the categories - meaning there are two envelopes for each award.