Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
While heavily dominated by French and English schools, accounting for 44 per cent of the table, the ranking is more diverse than ever with schools from 25 countries.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The Canadian city of Vancouver remains the most expensive location in North America, ranked 21st in the index.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.
在此次上榜的5所中国学院当中，上海高级金融学院排名最高，领先于北京大学光华管理学院(Guanghua School of Management at Peking University)和清华大学经济管理学院(School of Economics and Management, Tsinghua University)，后两家学院分别排名第17位和第18位。
The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
Anyone can have a bad day at the office, but this disappointing performance at Christie’s followed an old masters sale in July that took in 19 million against a low estimate of 31.5 million.
Trends and targets in antiviral phototherapy
《我无法忘记那天晚上和他在一起时发生的事》(‘I Could Not Forget What Happened to Me That Night With Him’)
"Poverty has stunted further growth in Internet users, which has kept the Net user population to around 50 percent," Li said.
“Even if you have made your peace with a Fed rate rise there are other reasons to be nervous,” said David Hauner, head of emerging markets at Bank of America Merrill Lynch, who points to falling oil prices and the slowdown in China to illustrate why market volatility measured by the CBOE’s Vix index, a barometer of investor sentiment, has been elevated since August.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
He argues, however, that “US monetary policy is often just as important as domestic factors in explaining the incidence of EM crises, if not more important.”
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Despite the breakthrough, Jack Ma, chairman of Alibaba Group, said there was no need for human beings to fear machines.
4. Booing isn't just for pantomimes
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
If the user set up a truthful answer, according to statistics provided by the researchers, in 19.7% of the cases, an attacker would need a single try to guess the correct answer to the question "What is your favorite food?" in the case of American users.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The import side of the equation fared worse in both renminbi- and dollar-terms.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Creditors have officially approved the MGM restructuring plan that will put Spyglass Entertainment in charge of the studio, getting it moving once again. MGM will no longer be a distributor, but a working studio, which now puts James Bond 23 on the auction block and closer to an actual start date. Here is the official announcement from MGM:
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
That figure is more than two times the city's population of about 10 million.
Antiviral drug discovery: broad-spectrum drugs from nature
有趣的是，“真诚的问候”(unfeigned regards)又重回我们的视野——人们现在可以在印度服务中心的邮件上见到这一18世纪末的流行语。而更胜一筹的是这个签名，一个周五我收到了一则消息，末尾处写到：“周末好”(weekend well)。我差点将最佳名词使动用法奖也颁给它，不料最后一刻却杀出一匹黑马，一位顾问无意中说了句：“我们能把那件事冷毛巾一下吗？”(Can we cold towel that?)
与此同时，布拉德福德大学管理学院(Bradford University School of Management)和爱丁堡大学商学院(University of Edinburgh Business School)的排名均上升16位，分别排在第42名和第55名。剑桥大学(University of Cambridge)佳奇管理学院(Judge Business School)的排名上升15位，排在第14名。
Influenza neuraminidase: A druggable target for natural products
Some people remain attached to a theory that can be described as resource scarcity. At its heart this theory suggests that resource development follows a linear pattern in which low-cost resources are developed first, meaning that most if not all future development must be more costly. Unfortunately the history of the industry does not support this view. If anything the experience of the past few decades suggests that the opposite is true.
May happiness follow you wherever you go!愿您幸福快乐，直到永远永远。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Mr Ford, founder of a Silicon Valley software development company, suggests “a fundamental restructuring of our economic rules” may be needed to mitigate the impact of the advance of robotics and automation. He proposes a guaranteed minimum basic income — or “citizen’s dividend” — as one radical remedy.
The role of biosensors in the detection of emerging infectious diseases
7. The legacy of a celebrated neuroscientist is contested
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Company: (Wonderbag) Natural Balance
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
It's important to remember that even when the overall number of jobs goes down, some companies are still adding workers -- it's just that others are cutting even more.
Will impeachment proceedings begin against Donald Trump
In 2012, Google introduced Google Glass, a computer you can wear on your face. Someone wearing the glasses can be walking down the street or doing any everyday task while simultaneously seeing an overlay of calendar appointments, messages, and subway alerts. They can make video calls and even upload live videos to the Internet while on the move, without ever needing to use their hands. Google Glass might be cool, it might be new, it might be revolutionary, but it's definitely not the first pair of wearable computer glasses.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
China's 16 listed banks have cut their dividend payouts for the past year amid slowing net profit growth.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
5. Emma Stone
Inhibition of SARS coronavirus helicase by bismuth complexes
The drama in Nafta
For generations, working-class whites were doubly blessed: they enjoyed privileged status based on race, as well as the fruits of broad economic growth.
Unemployment was the most searched for financial item, followed by "Wall Street companies" and "recalls".
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The show airs on CBS December 4.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Perhaps just as important, stable or falling prices will boost the inflation-adjusted pay of U.S. workers and gives them more bang for their buck. "It's an unambiguous positive for household demand," said Neil Dutta, head of economics at Renaissance Macro Research. "People will have more money to spend."
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
'We are quite confident that it should sell towards the high end of the estimate or above.'
Judge Business School at Cambridge University in the UK was the biggest riser, climbing 19 places to 29th thanks to a strong performance in the executive MBA ranking in its first participation in that list. Warwick Business School made a comeback to the top 20 (19) after missing out on the MiM ranking in 2013.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The upcoming launch will mark the five-year anniversary of the sinking of a South Korean warship in 2010, with the loss of 46 sailors. The South pinned the blame on the North and effectively froze all inter-Korean trade and investment ties.
The drama won much praise for its use of slow motion when shooting martial arts.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Everyone loves cookies, but buying a smart cookie oven to make them seems like a bit much. The CHIP cookie oven promises to have freshly baked cookies in just 10 minutes, but regardless of the time, it just seems easier to make a much larger batch using the regular old oven.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
vt. 作 ... 姿
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Vocal event of the year: "The Only Way I Know," Eric Church, Luke Bryan and Jason Aldean
Foreign property investment by Chinese companies plunged by 84 per cent last month, as Beijing’s capital controls choked off the flow of foreign acquisitions.
In 2010, the Martin Aircraft Company introduced a jetpack it called "the world's first piratical jetpack." The jetpack even won a spot in Time's Top 50 Inventions of 2010. While its development has been on since 1981, the world's first jetpack is known to have flown in 1958. It was designed by Wendell Moore, a researcher at Bells Aerosystems. Early prototypes of Wendell's jetpack could reach a height of 5 meters (16 ft) and remain airborne for three minutes. This attracted the attention of the US Army, which funded the project with $150,000. Several test flights were later done for the US Army and even for JFK himself. The army later stopped paying for more research into the project because the flight time and distance were not convincing enough. NASA also wanted to use the jetpack for their Apollo 11 mission to serve as backups in case their lunar module malfunctioned. They later changed their minds, going for the lunar rover instead. After this setback, Bell discontinued further research on the jetpack.
BuzzFeed News defined “fake news” as news that was verifiably “100 percent false” and drawn from a list of 96 websites purposely created to disseminate false information.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
5. Mother Nature
Mr. Nathan was among the few dealers actively bidding at the evening sales. Buying on behalf of a client, he paid 506,500, or twice the estimate, at Christie’s for Charles-Antoine Coypel’s 1737 painting, “The Destruction of the Palace of Armida.”
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
China’s forex reserves — the world’s largest — have long been seen as the ultimate guarantor of financial stability, since they can be used to hedge against capital flight or to bail out domestic financial institutions struggling with a rise in bad debts.
Phil Baty, editor of the rankings, said: "it seems that China's relentless march up the global league tables has stalled, after making major gains in recent years. This new data shows just how hard it is for emerging powers to break into the traditional global elite."
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Gongloff piles on the bad news about 2014: GDP 'grew at a 1.8% annualized pace in the first quarter ... revising down its earlier estimate of 2.4% growth ... The first quarter's dismal growth was at least better than the 0.4% GDP growth of the fourth quarter of 2012. But it was still far from healthy, and economists don't see it getting much stronger any time soon.' And that's real bad news for the markets going into 2014.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
If You're Unemployed:
2012中国创新人物奖中国互联网行业常常被描述成冒牌王国，尤其是对在中国被禁的那些公司的仿冒。中国搜索巨头百度(Baidu Inc.)的网站外观很像谷歌。腾讯的旗舰产品、即时信息服务QQ于1999年以OICQ的名字发布，与当时流行的即时信息服务ICQ功能相似。新浪(Sina Corp.)广受欢迎的微博总是被西方媒体说成“与推特(Twitter)类似”。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
That put outbound investment for October at $8.3bn, according to FT calculations based on official data, for a year-on-year fall of 26.5 per cent.
法国巴黎高等商学院排名第二，尽管该学院在除MBA以外的所有排名中都胜过伦敦商学院。法国巴黎高等商学院最终不敌伦敦商学院的原因是，其高管MBA课程Trium是与伦敦经济学院(London School of Economics)和纽约斯特恩商学院(Stern School of Business)合办的，因此这门课程在该项排名中的得分只有总得分的三分之一。（合办课程的商学院参与EMBA课程排名时按比例获得分值。）
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
但是，是什么推动了乐观或悲观情绪呢？库迪斯与巴塞罗那庞培法布拉大学(Universitat Pompeu Fabra)的汉斯-乔亚吉姆o沃斯发现了一些令人意外的答案。
A modular microarray imaging system for highly specific COVID-19 antibody testing
There are merely citizens whose choices not only may, but surely will, change.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Sales & Marketing
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Imports grew 3.1 per cent year-on-year in dollar terms to $168.6bn in December after growing a revised 4.7 per cent (previously 6.7 per cent) the previous month. That rate was roughly in line with a median forecast of 3 per cent growth.
5. Gay Marriage
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
Foreign property investment by Chinese companies plunged by 84 per cent last month, as Beijing’s capital controls choked off the flow of foreign acquisitions.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
7.Thought-Controlled Bionic Legs
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.
A facile assay for rapid detection of COVID-19 antibodies
How the longer maternity leave policy is implemented is up to local governments to decide. Specific and legally-binding measures should be worked out at the national level to ensure the policy is carried out and properly enforced to ensure that women are not discriminated against by employers obsessed with minimizing their labor costs.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Additional reporting by Ma Nan
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The group’s leader, Wang Rongzhen, told Reuters on Wednesday that the automaker has scaled back the range of models it supplies to dealers in Hyundai imports in China, only consistently supplying one model, while steadily increasing car manufacturing in China.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
China's property companies have been escalating promotional efforts and cutting prices in a bid to maintain sales volumes.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
《余秀华：从普通农妇到著名诗人》(A Chinese Poet’s Unusual Path From Isolated Farm Life to Celebrity)
Anti-HIV drug repurposing against SARS-CoV-2
Germany ranks No. 4 overall. The nation ranks No. 10 in Citizenship. It is also No. 1 in Entrepreneurship and No. 3 in Best Countries for Education.
Feng said that the Goal for 2017 is to maintain an overall punctuality rate of about 75%.
Length-scale dependence of protein hydration-shell density
For the dynasties that flourished in China around 1,700 years ago "the conquest and effective governance of Kucha would enable them to control all the oasis city-states in the Western Frontiers," the researchers said.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
“The employee said she was going out to buy boots, but was never seen again.”
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The impact will also ripple out to some net commodity importers, Mr Williams believes, with higher commodity prices likely to boost the price of resource-intensive manufactured goods such as steel, bolstering the value of exports from the like of South Korea.
Although Guo has not given any timetable for her retirement, her announcement at December's East Asian Games about a possible one-year hiatus is a clear enough signal. From all evidence, her relationship with Fok seems to have entered another stage. Unless they truly believe that the Chinese lunar calendar warns against a "widow's year" in 2010, we might well see Miss Guo become Mrs Fok.
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