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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

While heavily dominated by French and English schools, accounting for 44 per cent of the table, the ranking is more diverse than ever with schools from 25 countries.
冥想

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 特色小镇的核心是大写“特”字
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The Canadian city of Vancouver remains the most expensive location in North America, ranked 21st in the index.
在许多情况下,这种做法已经渐渐从政界边缘进入主流。比如说,英国的执政党保守党立场是中间偏右,它曾经推进英国脱欧,公投之后,新的保守党首相特丽莎?梅(Theresa May)表现出对白人身份政治的同情。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

stick

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

报告称,迪拜排名第四,预计接待游客1527万人,“突飞猛进,成为全球旅游消费最高的城市”。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.
在此次上榜的5所中国学院当中,上海高级金融学院排名最高,领先于北京大学光华管理学院(Guanghua School of Management at Peking University)和清华大学经济管理学院(School of Economics and Management, Tsinghua University),后两家学院分别排名第17位和第18位。
The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
Anyone can have a bad day at the office, but this disappointing performance at Christie’s followed an old masters sale in July that took in 19 million against a low estimate of 31.5 million.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

《我无法忘记那天晚上和他在一起时发生的事》(‘I Could Not Forget What Happened to Me That Night With Him’)
"Poverty has stunted further growth in Internet users, which has kept the Net user population to around 50 percent," Li said.
“Even if you have made your peace with a Fed rate rise there are other reasons to be nervous,” said David Hauner, head of emerging markets at Bank of America Merrill Lynch, who points to falling oil prices and the slowdown in China to illustrate why market volatility measured by the CBOE’s Vix index, a barometer of investor sentiment, has been elevated since August.
年龄:46岁

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

He argues, however, that “US monetary policy is often just as important as domestic factors in explaining the incidence of EM crises, if not more important.”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

银行业

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Despite the breakthrough, Jack Ma, chairman of Alibaba Group, said there was no need for human beings to fear machines.
4. Booing isn't just for pantomimes

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

他在一则电话采访中向汤森路透基金会透露:“外出打工应该只是一个选择。但是对于2亿人来说,却是没得选择的选择。”
除了作品被展示在谷歌主页,张天羽还获得了3万美元的大学奖学金。她所在的学校也将获得5万美元的谷歌教育科技拨款。谷歌还以她的名义向慈善机构捐赠了2万美元,用于给孟加拉的学校提供净水。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

['elim?nt]
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

肠道细菌正以我们想像不到的方式干扰着我们。新的研究指出,像帕金森综合症等神经退行性疾病实际上可能始于肠道,而不是大脑。越来越多的证据显示,慢性疲劳综合征可能要归咎于人体内的微生物群系。随着肠道细菌显示出控制食欲以及改变大脑结构的迹象,而且有引起大脑损伤而导致中风的表现,我们的这个小过客(肠道细菌)有着不容忽视的力量。
认真思考一下:未来的经历能提高你的知识和技能吗?它是否会让你接触到新的观点,认识不同的人?(这些都是支持你对机会说“Yes”的好理由!)你需要为了管理团队或与经验更加丰富的同事共事而培养新技巧吗?如果答案是肯定的,那就接受这种挑战,走出你的舒适区。
If the user set up a truthful answer, according to statistics provided by the researchers, in 19.7% of the cases, an attacker would need a single try to guess the correct answer to the question "What is your favorite food?" in the case of American users.
这一消息来自英国时装协会,协会在时装周前对设计师进行了调查,发现在9月份的时装周登场的80名设计师中没有一位会使用皮草。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

The import side of the equation fared worse in both renminbi- and dollar-terms.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

英国《泰晤士高等教育》专刊于上周四公布的一项调查显示,中国内地两所高校入选亚洲大学前三名。
port部分+ion→一部分→部分,一般

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Creditors have officially approved the MGM restructuring plan that will put Spyglass Entertainment in charge of the studio, getting it moving once again. MGM will no longer be a distributor, but a working studio, which now puts James Bond 23 on the auction block and closer to an actual start date. Here is the official announcement from MGM:

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

That figure is more than two times the city's population of about 10 million.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

英国新人结婚模仿“怪物史瑞克”(图)
有趣的是,“真诚的问候”(unfeigned regards)又重回我们的视野——人们现在可以在印度服务中心的邮件上见到这一18世纪末的流行语。而更胜一筹的是这个签名,一个周五我收到了一则消息,末尾处写到:“周末好”(weekend well)。我差点将最佳名词使动用法奖也颁给它,不料最后一刻却杀出一匹黑马,一位顾问无意中说了句:“我们能把那件事冷毛巾一下吗?”(Can we cold towel that?)
与此同时,布拉德福德大学管理学院(Bradford University School of Management)和爱丁堡大学商学院(University of Edinburgh Business School)的排名均上升16位,分别排在第42名和第55名。剑桥大学(University of Cambridge)佳奇管理学院(Judge Business School)的排名上升15位,排在第14名。
语言本是人们沟通的工具,没有性别之分,但由于男女的社会分工、性格特色、生理特点不同,每一种语言都深深地打上了性别的烙印。在国外,有部分社会语言学家,专门研究语言

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

Dunkirk
单词reform 联想记忆:
Some people remain attached to a theory that can be described as resource scarcity. At its heart this theory suggests that resource development follows a linear pattern in which low-cost resources are developed first, meaning that most if not all future development must be more costly. Unfortunately the history of the industry does not support this view. If anything the experience of the past few decades suggests that the opposite is true.
美国人星期一庆祝哥伦布日。每年十月第二个星期一是纪念哥伦布到达美洲的哥伦布日,属于联邦假日。意大利探险家哥伦布受命西班牙国王,四次率领船队探索新世界,但从来没有完成他最初的目标,也就是找到一条向西通往亚洲的海上航线。哥伦布为探险者开辟了美洲大陆,使世界历史进入一个新时代。
May happiness follow you wherever you go!愿您幸福快乐,直到永远永远。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Mr Ford, founder of a Silicon Valley software development company, suggests “a fundamental restructuring of our economic rules” may be needed to mitigate the impact of the advance of robotics and automation. He proposes a guaranteed minimum basic income — or “citizen’s dividend” — as one radical remedy.
随着威斯布鲁克成为一个事事亲为和高使用率的角色,奥拉迪波固定成为一个昂贵的补充品,佩恩需要证明他无球时的威胁力、或是能成为带动第二阵容的后卫,

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

7. The legacy of a celebrated neuroscientist is contested

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Company: (Wonderbag) Natural Balance

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

It's important to remember that even when the overall number of jobs goes down, some companies are still adding workers -- it's just that others are cutting even more.
即便这些改进最终会降低长期成本,遵守这条法律可能还是颇具挑战性。此外,2015年是各楼盘停用6号取暖油、改用污染更少的4号油的最后期限。
Will impeachment proceedings begin against Donald Trump
In 2012, Google introduced Google Glass, a computer you can wear on your face. Someone wearing the glasses can be walking down the street or doing any everyday task while simultaneously seeing an overlay of calendar appointments, messages, and subway alerts. They can make video calls and even upload live videos to the Internet while on the move, without ever needing to use their hands. Google Glass might be cool, it might be new, it might be revolutionary, but it's definitely not the first pair of wearable computer glasses.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

n. 决定,决策
伊格尔说:“他非常、非常善于不让这些压力以任何方式破坏苹果正在努力实现的目标。库克的脑海里无疑有要操心的问题,但他确保专门从事苹果最擅长工作的人才不必操心这些问题。”
本文为与《时代》杂志的合作内容。
China's 16 listed banks have cut their dividend payouts for the past year amid slowing net profit growth.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 建材行业流通业态发展趋势的思考
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

5. Emma Stone
8月7日

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 立邦绿建·无忧之旅走进武汉
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

国家统计局日前在其网站发布了上述数据,称这是科技研发经费增速连续4年下滑后的首次回升。
The drama in Nafta
For generations, working-class whites were doubly blessed: they enjoyed privileged status based on race, as well as the fruits of broad economic growth.
为什么我如此有信心东亚不会爆发战争,无论在东中国海还是南中国海?答案很简单,因为我了解推动亚洲变化的力量。虽然许多亚洲邻国会发出愤怒的民族主义声明(他们必须这样做来应对普遍的民族主义情绪),但他们的行动是谨慎和务实的。
Unemployment was the most searched for financial item, followed by "Wall Street companies" and "recalls".

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

vt. 起草,征
vt. 忽视,疏忽,忽略
The show airs on CBS December 4.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 民法典物权编草案首提“居住权”
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

高效老板和经理们趋向于:
Perhaps just as important, stable or falling prices will boost the inflation-adjusted pay of U.S. workers and gives them more bang for their buck. "It's an unambiguous positive for household demand," said Neil Dutta, head of economics at Renaissance Macro Research. "People will have more money to spend."

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 钢铁业大调整 寒冬还未到来
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

'We are quite confident that it should sell towards the high end of the estimate or above.'
Judge Business School at Cambridge University in the UK was the biggest riser, climbing 19 places to 29th thanks to a strong performance in the executive MBA ranking in its first participation in that list. Warwick Business School made a comeback to the top 20 (19) after missing out on the MiM ranking in 2013.
接受一份谋生型的工作有两个弊端。这样做会让你在求职中分心,而且潜在雇主对你以前的专业形象会有所怀疑。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

住在气球发射场附近的边境民众投诉活动分子将他们的生命置于危险之中,因为他们是北韩反击的潜在受害者。
The upcoming launch will mark the five-year anniversary of the sinking of a South Korean warship in 2010, with the loss of 46 sailors. The South pinned the blame on the North and effectively froze all inter-Korean trade and investment ties.
The drama won much praise for its use of slow motion when shooting martial arts.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

frame

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Everyone loves cookies, but buying a smart cookie oven to make them seems like a bit much. The CHIP cookie oven promises to have freshly baked cookies in just 10 minutes, but regardless of the time, it just seems easier to make a much larger batch using the regular old oven.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

vt. 作 ... 姿
但国家统计局认为,CPI上涨的主要原因是去年同期对比基数相对偏低。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Vocal event of the year: "The Only Way I Know," Eric Church, Luke Bryan and Jason Aldean
Foreign property investment by Chinese companies plunged by 84 per cent last month, as Beijing’s capital controls choked off the flow of foreign acquisitions.
In 2010, the Martin Aircraft Company introduced a jetpack it called "the world's first piratical jetpack." The jetpack even won a spot in Time's Top 50 Inventions of 2010. While its development has been on since 1981, the world's first jetpack is known to have flown in 1958. It was designed by Wendell Moore, a researcher at Bells Aerosystems. Early prototypes of Wendell's jetpack could reach a height of 5 meters (16 ft) and remain airborne for three minutes. This attracted the attention of the US Army, which funded the project with $150,000. Several test flights were later done for the US Army and even for JFK himself. The army later stopped paying for more research into the project because the flight time and distance were not convincing enough. NASA also wanted to use the jetpack for their Apollo 11 mission to serve as backups in case their lunar module malfunctioned. They later changed their minds, going for the lunar rover instead. After this setback, Bell discontinued further research on the jetpack.
BuzzFeed News defined “fake news” as news that was verifiably “100 percent false” and drawn from a list of 96 websites purposely created to disseminate false information.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

周三,北京市市委宣布,计划将绝大部分的北京市政府部门在2017年迁至通州区。
从2004年起,过去120年里的现代或当代艺术家们创作的10件作品在拍卖会上共卖出1亿多美元。而更早期绘画大师的作品价格则是稳中有跌。最近几周,这一趋势非常明显,伦敦的拍卖公司努力为自己的最新一批18世纪前绘画大师作品寻找买家。与近些年的情况一样,其中几乎没有名作。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 盘点10大恶炒的家居“概念”
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
获奖者:布兰妮·斯皮尔斯

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 江西南康家具产业提升品牌竞争力
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

vt. 忽视,疏忽,忽略

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

5. Mother Nature
眼看11月就要过去了,正如我周一写的那样,往年经验表明,9支球队很有可能已经被踢出季后赛地竞争行列了。然而,他们中没有一支球队表明要摆烂。
4月,著名电视节目主持人毕福剑的一段视频在网上流传。在视频中,他以文革时期的京剧剧目调侃国共内战,并夹杂了他个人对毛泽东和共产党的批评。尽管政府竭力阻止,这则视频仍广为流传,更有评论支持毕福剑的意见并捍卫他的言论自由。
Mr. Nathan was among the few dealers actively bidding at the evening sales. Buying on behalf of a client, he paid 506,500, or twice the estimate, at Christie’s for Charles-Antoine Coypel’s 1737 painting, “The Destruction of the Palace of Armida.”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 家居业:正在崛起的“中国制造”
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

China’s forex reserves — the world’s largest — have long been seen as the ultimate guarantor of financial stability, since they can be used to hedge against capital flight or to bail out domestic financial institutions struggling with a rise in bad debts.
Phil Baty, editor of the rankings, said: "it seems that China's relentless march up the global league tables has stalled, after making major gains in recent years. This new data shows just how hard it is for emerging powers to break into the traditional global elite."

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

10.你真的很明显,好吧?
Gongloff piles on the bad news about 2014: GDP 'grew at a 1.8% annualized pace in the first quarter ... revising down its earlier estimate of 2.4% growth ... The first quarter's dismal growth was at least better than the 0.4% GDP growth of the fourth quarter of 2012. But it was still far from healthy, and economists don't see it getting much stronger any time soon.' And that's real bad news for the markets going into 2014.
怎样写简历?

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

英国的一个收集全球气温纪录的科学小组也将在未来几周内提交报告。
If You're Unemployed:
2012中国创新人物奖中国互联网行业常常被描述成冒牌王国,尤其是对在中国被禁的那些公司的仿冒。中国搜索巨头百度(Baidu Inc.)的网站外观很像谷歌。腾讯的旗舰产品、即时信息服务QQ于1999年以OICQ的名字发布,与当时流行的即时信息服务ICQ功能相似。新浪(Sina Corp.)广受欢迎的微博总是被西方媒体说成“与推特(Twitter)类似”。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

That put outbound investment for October at $8.3bn, according to FT calculations based on official data, for a year-on-year fall of 26.5 per cent.
法国巴黎高等商学院排名第二,尽管该学院在除MBA以外的所有排名中都胜过伦敦商学院。法国巴黎高等商学院最终不敌伦敦商学院的原因是,其高管MBA课程Trium是与伦敦经济学院(London School of Economics)和纽约斯特恩商学院(Stern School of Business)合办的,因此这门课程在该项排名中的得分只有总得分的三分之一。(合办课程的商学院参与EMBA课程排名时按比例获得分值。)

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 2018广州楼市主基调:平稳
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

尽管中国的私人财富大幅增长,但中国的亿万富豪仍未跻身全球顶级富豪行列。胡润估计,中国首富、万达集团(Wanda Group)掌门人王健林在全球富豪中排名第26位。
欧洲工商管理学院的出类拔萃不仅表现在一年期MBA课程上,还体现于强大的国际文化(基于两个校区)以及覆盖面最广和最多样化的校友网络之一。该课程在校友国际流动性指标上排名第三,在国际课程体验指标上排名第六。
但是,是什么推动了乐观或悲观情绪呢?库迪斯与巴塞罗那庞培法布拉大学(Universitat Pompeu Fabra)的汉斯-乔亚吉姆o沃斯发现了一些令人意外的答案。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

n. 诱惑力,吸引力
There are merely citizens whose choices not only may, but surely will, change.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Miley Cyrus
译者:清远
TOP SONGS

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Sales & Marketing

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 国外建材大佬中国水土不服
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Imports grew 3.1 per cent year-on-year in dollar terms to $168.6bn in December after growing a revised 4.7 per cent (previously 6.7 per cent) the previous month. That rate was roughly in line with a median forecast of 3 per cent growth.
5. Gay Marriage

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
Foreign property investment by Chinese companies plunged by 84 per cent last month, as Beijing’s capital controls choked off the flow of foreign acquisitions.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: “复合32.5”水泥停产倒计时
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 区域一体化催生长三角发展新动能
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Dunkirk
7.Thought-Controlled Bionic Legs

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

全球其他地区能加以配合吗?
Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

How the longer maternity leave policy is implemented is up to local governments to decide. Specific and legally-binding measures should be worked out at the national level to ensure the policy is carried out and properly enforced to ensure that women are not discriminated against by employers obsessed with minimizing their labor costs.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

居民消费价格上涨2%;
但科学研究和技术服务领域企业的高管薪酬却下降了4.2%。
[ni'glekt]
competition

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Additional reporting by Ma Nan

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

The group’s leader, Wang Rongzhen, told Reuters on Wednesday that the automaker has scaled back the range of models it supplies to dealers in Hyundai imports in China, only consistently supplying one model, while steadily increasing car manufacturing in China.
8月24日
QuikTrip:“糖果摊”

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 棚改货币化安置应适时退潮
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

这位备受欢迎的英国女孩莉莉·唐纳森曾担任过“Vogue”这类时尚杂志的封面女郎,她展示了自己性感迷人的夏装,身着一件白色半透明的抹胸连衣裙参加了此次活动。这位三十岁的模特穿着一件近乎透明的礼服,看上去漂亮极了。
China's property companies have been escalating promotional efforts and cutting prices in a bid to maintain sales volumes.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 深度贫困地区可灵活使用宅基地
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

祝节日快乐,新年幸福。
答:这是我第一次去旧金山。非常美丽的城市。到那儿的第一天我们就去看了金门大桥。海湾的景色真是让人愉悦啊。我在日本每次看电影,这个城市和这个桥都要被毁一次。但我从不知道这个城市亲眼看的话居然有这么美。下次再来可能就没机会看这座桥了,所以我很高兴这次能看到。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

《余秀华:从普通农妇到著名诗人》(A Chinese Poet’s Unusual Path From Isolated Farm Life to Celebrity)

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Germany ranks No. 4 overall. The nation ranks No. 10 in Citizenship. It is also No. 1 in Entrepreneurship and No. 3 in Best Countries for Education.
Feng said that the Goal for 2017 is to maintain an overall punctuality rate of about 75%.
Intel

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

adj. 创造性的
伦敦商学院今年在英国《金融时报》每年发布的4项排名中的表现,令其在欧洲最优秀的81所商学院中拔得头筹,这4项排名是:MBA、高管MBA(EMBA)、管理硕士(MiM)以及高管教育。(有两所商学院因得分相同并列第80位。)
For the dynasties that flourished in China around 1,700 years ago "the conquest and effective governance of Kucha would enable them to control all the oasis city-states in the Western Frontiers," the researchers said.
怎么挑染头发

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

据《21世纪经济报道》称,广东去年的GDP增速为7.5%。
“The employee said she was going out to buy boots, but was never seen again.”

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The impact will also ripple out to some net commodity importers, Mr Williams believes, with higher commodity prices likely to boost the price of resource-intensive manufactured goods such as steel, bolstering the value of exports from the like of South Korea.
Although Guo has not given any timetable for her retirement, her announcement at December's East Asian Games about a possible one-year hiatus is a clear enough signal. From all evidence, her relationship with Fok seems to have entered another stage. Unless they truly believe that the Chinese lunar calendar warns against a "widow's year" in 2010, we might well see Miss Guo become Mrs Fok.
这个位于非洲西南部的国家拥有20多家国家公园以及世界上最古老的沙漠。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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排名:第三
《佛罗里达乐园》

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